Abstract: Improving Wound Healing Using α-gal: Antibody Stimulated Macrophage Directed Wound Healing
نویسندگان
چکیده
Materials and Methods: Our study prospectively evaluates outcomes in 9 patients treated with the “SUFA” technique (Subcision and Fat Grafting) for debilitating contracted burn scars limiting range of motion. Results are evaluated clinically with the Vancouver scale and by range of motion through the affected joints at 1, 3, 6 and 12 months. Scientific validation of the outcomes is performed evaluating dermal thickening and scar remodeling by high definition ultrasound and histology examination with hematoxylin-eosin and monoclonal antibodies staining.
منابع مشابه
Acceleration of Wound Healing by α-gal Nanoparticles Interacting with the Natural Anti-Gal Antibody
Application of α-gal nanoparticles to wounds and burns induces accelerated healing by harnessing the natural anti-Gal antibody which constitutes ~1% of human immunoglobulins. α-gal nanoparticles present multiple α-gal epitopes (Galα1-3Galβ1-4GlcNAc-R), the carbohydrate ligand of anti-Gal. Studied α-gal nanoparticles were comprised of glycolipids with α-gal epitopes, phospholipids, and cholester...
متن کاملRapid recruitment and activation of macrophages by anti-Gal/α-Gal liposome interaction accelerates wound healing.
Macrophages are pivotal in promoting wound healing. We hypothesized that topical application of liposomes with glycolipids that carry Galα1-3Galβ1-4GlcNAc-R epitopes (α-gal liposomes) on wounds may accelerate the healing process by rapid recruitment and activation of macrophages in wounds. Immune complexes of the natural anti-Gal Ab (constituting ∼1% of Ig in humans) bound to its ligand, the α-...
متن کاملAcceleration of wound healing by alpha-gal nanoparticles interacting with the natural anti-Gal antibody
This work is licensed under a Creative Commons Attribution 3.0 License. Galili, Uri, "Acceleration of wound healing by alpha-gal nanoparticles interacting with the natural anti-Gal antibody" (2015).
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Diabetes is associated with persistent inflammation and defective tissue repair responses. The hypothesis of this study was that interleukin (IL)-1β is part of a proinflammatory positive feedback loop that sustains a persistent proinflammatory wound macrophage phenotype that contributes to impaired healing in diabetes. Macrophages isolated from wounds in diabetic humans and mice exhibited a pro...
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Diabetes is associated with persistent inflammation and defective tissue repair responses. The hypothesis of this study was that interleukin (IL)-1b is part of a proinflammatory positive feedback loop that sustains a persistent proinflammatory wound macrophage phenotype that contributes to impaired healing in diabetes. Macrophages isolated from wounds in diabetic humans and mice exhibited a pro...
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2016